Seal whiskers vibrate over broad frequencies during hydrodynamic tracking

© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 7 (2017): 8350, doi:10.1038/s41598-017-07676-w.Although it is known that seals can use their whiskers (vibrissae) to extract relevant information from complex underwater flow fields, the underlying functioning of the system and the signals received by the sensors are poorly understood. Here we show that the vibrations of seal whiskers may provide information about hydrodynamic events and enable the sophisticated wake-tracking abilities of these animals. We developed a miniature accelerometer tag to study seal whisker movement in situ. We tested the ability of the tag to measure vibration in excised whiskers in a flume in response to laminar flow and disturbed flow. We then trained a seal to wear the tag and follow an underwater hydrodynamic trail to measure the whisker signals available to the seal. The results showed that whiskers vibrated at frequencies of 100–300 Hz, with a dynamic response. These measurements are the first to capture the incoming signals received by the vibrissae of a live seal and show that there are prominent signals at frequencies where the seal tactogram shows good sensitivity. Tapping into the mechanoreceptive interface between the animal and the environment may help to decipher the functional basis of this extraordinary hydrodynamic detection ability.Funding was provided by the NSF GRFP and NISE section 219 to C. Murphy and by the Office of Naval Research (N000141910468) to B. Calhoun

Towards a Critical Sociology of Dominant Ideologies: An Unexpected Reunion between Pierre Bourdieu and Luc Boltanski

This article aims to demonstrate the enduring relevance of Pierre Bourdieu and Luc Boltanski’s ‘La production de l’idéologie dominante’ [‘The production of the dominant ideology’], which was originally published in Actes de la recherche en sciences sociales in 1976. More than three decades later, in 2008, a re-edited version of this study was printed in book format as La production de l’idéologie dominante, which was accompanied by a detailed commentary, written by Luc Boltanski and entitled Rendre la réalité inacceptable. À propos de « La production de l’idéologie dominante » [Making Reality Unacceptable. Comments on ‘The production of the dominant ideology’]. In addition to containing revealing personal anecdotes and providing important sociological insights, this commentary offers an insider account of the genesis of one of the most seminal pieces Boltanski co-wrote with his intellectual father, Bourdieu. In the Anglophone literature on contemporary French sociology, however, the theoretical contributions made both in the original study and in Boltanski’s commentary have received little – if any – serious attention. This article aims to fill this gap in the literature, arguing that these two texts can be regarded not only as forceful reminders of the fact that the ‘dominant ideology thesis’ is far from obsolete but also as essential for understanding both the personal and the intellectual underpinnings of the tension-laden relationship between Bourdieu and Boltanski. Furthermore, this article offers a critical overview of the extent to which the unexpected, and partly posthumous, reunion between ‘the master’ (Bourdieu) and his ‘dissident disciple’ (Boltanski) equips us with powerful conceptual tools, which, whilst illustrating the continuing centrality of ‘ideology critique’, permit us to shed new light on key concerns in contemporary sociology and social theory. Finally, the article seeks to push the debate forward by reflecting upon several issues that are not given sufficient attention by Bourdieu and Boltanski in their otherwise original and insightful enquiry into the complexities characterizing the daily production of ideology

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease

BACKGROUND: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization. RESULTS: During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events. CONCLUSIONS: Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)

Circuit techniques for subthreshold leakage reduction in a deep sub-micron process

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.Includes bibliographical references (p. 115-118).by Benton Highsmith Calhoun.S.M

An Ultra-Low Energy Subthreshold SRAM Bitcell for Energy Constrained Biomedical Applications

Energy consumption is a key issue in portable biomedical devices that require uninterrupted biomedical data processing. As the battery life is critical for the user, these devices impose stringent energy constraints on SRAMs and other system on chip (SoC) components. Prior work shows that operating CMOS circuits at subthreshold supply voltages minimizes energy per operation. However, at subthreshold voltages, SRAM bitcells are sensitive to device variations, and conventional 6T SRAM bitcell is highly vulnerable to readability related errors in subthreshold operation due to lower read static noise margin (RSNM) and half-select issue problems. There are many robust subthreshold bitcells proposed in the literature that have some improvements in RSNM, write static noise margin (WSNM), leakage current, dynamic energy, and other metrics. In this paper, we compare our proposed bitcell with the state of the art subthreshold bitcells across various SRAM design knobs and show their trade-offs in a column mux scenario from the energy and delay metrics and the energy per operation metric standpoint. Our 9T half-select-free subthreshold bitcell has 2.05× lower mean read energy, 1.12× lower mean write energy, and 1.28× lower mean leakage current than conventional 8T bitcells at the TT_0.4V_27C corner. Our bitcell also supports the bitline interleaving technique that can cope with soft errors

A DC-DC Converter Efficiency Model for System Level Analysis in Ultra Low Power Applications

This paper presents a model of inductor based DC-DC converters that can be used to study the impact of power management techniques such as dynamic voltage and frequency scaling (DVFS). System level power models of low power systems on chip (SoCs) and power management strategies cannot be correctly established without accounting for the associated overhead related to the DC-DC converters that provide regulated power to the system. The proposed model accurately predicts the efficiency of inductor based DC-DC converters with varying topologies and control schemes across a range of output voltage and current loads. It also accounts for the energy and timing overhead associated with the change in the operating condition of the regulator. Since modern SoCs employ power management techniques that vary the voltage and current loads seen by the converter, accurate modeling of the impact on the converter efficiency becomes critical. We use this model to compute the overall cost of two power distribution strategies for a SoC with multiple voltage islands. The proposed model helps us to obtain the energy benefits of a power management technique and can also be used as a basis for comparison between power management techniques or as a tool for design space exploration early in a SoC design cycle